Flurbiprofen concentration in soft tissues is higher after topical application than after oral administration
Article first published online: 5 FEB 2013
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society
British Journal of Clinical Pharmacology
Special Issue: Nutraceuticals Themed Section
Volume 75, Issue 3, pages 799–804, March 2013
How to Cite
Kai, S., Kondo, E., Kawaguchi, Y., Kitamura, N. and Yasuda, K. (2013), Flurbiprofen concentration in soft tissues is higher after topical application than after oral administration. British Journal of Clinical Pharmacology, 75: 799–804. doi: 10.1111/j.1365-2125.2012.04394.x
- Issue published online: 5 FEB 2013
- Article first published online: 5 FEB 2013
- Accepted manuscript online: 24 JUL 2012 02:39AM EST
- Manuscript Accepted: 5 JUL 2012
- Manuscript Received: 13 JAN 2012
- Hokkaido University Graduate School of Medicine
- plasma concentration;
- tissue concentration;
- topical application
To compare tissue concentrations of flurbiprofen resulting from topical application and oral administration according to the regulatory approved dosing guidelines.
Sixteen patients were included in this study. Each patient was randomly assigned to the topical application or oral administration group. In each group, a pair of tapes or a tablet, containing a total of 40 mg flurbiprofen, was administered twice at 16 and 2 h before the surgery.
The flurbiprofen concentration in the fat, tendon, muscle and periosteum tissues was significantly higher (P < 0.0330) after topical application (992 ng g−1 [95% CI 482, 1503], 944 [95% CI 481, 1407], 492 [95% CI 248, 735], and 455 [95% CI 153, 756], respectively) than after oral administration (150 ng g−1 [95% CI 84, 217], 186 [95% CI 118, 254], 82 [95% CI 49, 116],and 221 [95% CI, 135, 307], respectively).
Topical application is an effective method to deliver flurbiprofen to the human body, particularly to soft tissues near the body surface.