Flurbiprofen concentration in soft tissues is higher after topical application than after oral administration

Authors


Correspondence

Professor Kazunori Yasuda MD PhD, Department of Sports Medicine and Joint Surgery, Hokkaido University School of Medicine, Kita-15 Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.

Tel.: +81 11 706 7211

Fax: +81 11 706 7822

E-mail: yasukaz@med.hokudai.ac.jp

Abstract

Aim

To compare tissue concentrations of flurbiprofen resulting from topical application and oral administration according to the regulatory approved dosing guidelines.

Method

Sixteen patients were included in this study. Each patient was randomly assigned to the topical application or oral administration group. In each group, a pair of tapes or a tablet, containing a total of 40 mg flurbiprofen, was administered twice at 16 and 2 h before the surgery.

Results

The flurbiprofen concentration in the fat, tendon, muscle and periosteum tissues was significantly higher (P < 0.0330) after topical application (992 ng g−1 [95% CI 482, 1503], 944 [95% CI 481, 1407], 492 [95% CI 248, 735], and 455 [95% CI 153, 756], respectively) than after oral administration (150 ng g−1 [95% CI 84, 217], 186 [95% CI 118, 254], 82 [95% CI 49, 116],and 221 [95% CI, 135, 307], respectively).

Conclusion

Topical application is an effective method to deliver flurbiprofen to the human body, particularly to soft tissues near the body surface.

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