CHRONIC HYPERPLASTTC CANDIDIASIS—CANDIDAL LEUKOPLAKIA

Authors


Abstract

SUMMARY. Twelve cases of chronic hyperplastic candidiasis of the oral mucosa are described.

Clinically the lesions could not be reliably differentiated from “leukoplakia” due to other causes. All but 2 of the patients were otherwise healthy.

The histological appearances were distinctive: there was invasion by hyphae of C. albicans of the superficial epithelium of an acanthotic and parakeratotic plaque, associated with a characteristic intraepithelial inflammatory reaction.

In 9 cases the antibody titres to C. albicans in serum and saliva supported a diagnosis of candidiasis.

The response of the lesions to oral Nystatin was good in 3 cases and incomplete in 4.

The evidence that C. albicans plays an essential causative rather than a secondary role is critically discussed.

Recognition of chronic hyperplastic candidiasis from other “leukoplakias” is of practical importance since this condition is potentially reversible by medical treatment.

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