SUMMARY. Seventeen patients with widespread psoriasis were treated with parenteral methotrexate over a period of 2–88 weeks. The injections were given every 1–4 weeks, in a dose of 12·5–37·5 mg.
The best results were obtained with a dose of 25 mg. of methotrexate once weekly. The improvement can be maintained only by continued treatment.
One of our patients suffered from psoriasis and systemic lupus erythematosus; both conditions were improved.
Apart from nausea and leukopenia no complications or side effects were noted. However, methotrexate is a potentially dangerous agent which should be administered only under careful hospital supervision.
In the light of our experience we feel that methotrexate in the treatment of psoriasis deserves further investigation.