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THE RATE OF ABSORPTION AND DURATION OF ACTION OF FOUR DIFFERENT SOLUTIONS OF METHYL NICOTINATE*
Article first published online: 29 JUL 2006
British Journal of Dermatology
Volume 81, Issue 3, pages 202–206, March 1969
How to Cite
FOUNTAIN, R. B., BAKER, B. S., HADGRAFT, J. W. and SARKANY, I. (1969), THE RATE OF ABSORPTION AND DURATION OF ACTION OF FOUR DIFFERENT SOLUTIONS OF METHYL NICOTINATE. British Journal of Dermatology, 81: 202–206. doi: 10.1111/j.1365-2133.1969.tb16008.x
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
- Accepted for publication July 14th, 1968.
SUMMARY.— The rate of absorption of methyl nicotinate dissolved in water, polyethylene glycol 300, propylene glycol and tetrahydrofurfuryl alcohol was studied by measuring, in vivo, the area and duration of the erythema which it produced.
With all the solutions it was found that the slower the absorption the longer was the duration of action. This relationship did not alter, either with different sites on the back, or at different ambient temperatures.
Methyl nicotinate was absorbed more quickly from the upper than the lower back. It was also absorbed more rapidly at higher ambient temperatures. Altering the concentration of methyl nicotinate between 0·25% and 1% did not change its rate of absorption although it increased the intensity of the reaction.