Requests for reprints should be addressed to Dr H. Baker, The London Hospital, London, E.1, U.K.
INTERMITTENT HIGH DOSE ORAL METHOTREXATE THERAPY IN PSORIASIS*
Article first published online: 29 JUL 2006
British Journal of Dermatology
Volume 82, Issue 1, pages 65–69, January 1970
How to Cite
BAKER, H. (1970), INTERMITTENT HIGH DOSE ORAL METHOTREXATE THERAPY IN PSORIASIS. British Journal of Dermatology, 82: 65–69. doi: 10.1111/j.1365-2133.1970.tb02194.x
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
- Accepted for publication May 21st, 1969.
SUMMARY.— Eighteen patients with intractable or severe psoriasis have been treated for up to 28 months with intermittent large oral doses of methotrexate. The disease was completely controlled in 9 and partially controlled in 5 patients. Severe clinical side-effects were seen in 5 patients, in 4 of whom therapy had to he abandoned. These effects were severe abdominal pain and vomiting in 2; reactivation of colitis, serious ataxia, and epidermal necrolysis in 1 patient each. Concurrent administration of aspirin probably contributed to toxicity by potentiating the action of methotrexate in 2 of these cases.
No serious haematological or biochemical abnormalities developed but mild transient leucopenia occurred in 2, thrombocytopenia in 1, and raised serum transaminases in 7.