Steroid-induced atrophy in an animal and human model
Article first published online: 29 JUL 2006
British Journal of Dermatology
Volume 94, Issue Supplement s12, pages 111–119, March 1976
How to Cite
KIRBY, J. D. and MUNRO, D.D. (1976), Steroid-induced atrophy in an animal and human model. British Journal of Dermatology, 94: 111–119. doi: 10.1111/j.1365-2133.1976.tb02279.x
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
A ratchet-controlled micrometer screw gauge has been used to measure the changes in skin thickness produced by topical corticosteroids.
Measurable thinning of the mouse ear followed repeated daily application of corticosteroids. This response in the animal was used to assess the atrophic potential in a variety of standard formulations. The same compounds were applied to human skin and the changes in thickness measured.
Patterns of response and the rank order of thinning obtained from the animal model were found to parallel closely the human results.