Prostaglandins and pruritus*


  • *

    Based on a paper read at the 1975 Meeting of the Investigative Group of the B.A.D.


We have found that pretreatment of human skin with prostaglandin El significantly lowers the threshold of human skin to itching evoked by both histamine and papain. Prostaglandins may thus potentiate pruritus in inflammatory skin disease, presumably by a non-specific effect on nerve-endings.