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The effect of long term tetracycline treatment for acne vulgaris on the occurrence of R factors in the intestinal flora of man
Article first published online: 29 JUL 2006
DOI: 10.1111/j.1365-2133.1976.tb07019.x
1365-2133/asset/cover.gif?v=1&s=413074e1e506a67a21dcc4e2de9ff9b6ce256d16 "British Journal of Dermatology")
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How to Cite
VALTONEN, M., VALTONEN, V., SALO, O. and MÄKELÄ, P. (1976), The effect of long term tetracycline treatment for acne vulgaris on the occurrence of R factors in the intestinal flora of man. British Journal of Dermatology, 95: 311–316. doi: 10.1111/j.1365-2133.1976.tb07019.x
Publication History
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
- Accepted for publication 22 January 1976
- Abstract
- References
- Cited By
SUMMARY
R factors are known to be the most important mechanism of antimicrobial resistance of intestinal flora. Short courses with therapeutic doses (1000 mg/day) of tetracycline select for strains containing transferable resistance factors to more than one antimicrobial agent. In this report we show that long term treatment with very low doses (100 mg/day) of tetracycline for acne vulgaris has an equally strong effect favouring establishment of resistant strains and R factors in the intestinal flora of patients.