Herpetiform pemphigus induced by penicillamine



A patient with arthritis is described who developed a dermatitis herpetiformis-like rash after 8 months of D-penicillamine therapy and which cleared soon after the drug was discontinued. The histopathologicat findings were compatible with a diagnosis of pemphigus, showing intra-epidermal vesicles and spongiosis but no acantholysis.

Intercellular antibody was detected by indirect immunofiuorescence at the onset of the eruption (titre I in 160) and also found in serum taken prior to penicillamine treatment (titre i in 20). It is now well known that D-penicillamine can induce pemphigus. The findings reported here suggest the possibility that the patient was predisposed to develop the eruption before the drug was given.