Cellular immunity to P. acnes in the normal population and patients with acne vulgaris


address: Professor G. Gowland, University Department of Immunology, Wellcome Wing, The General Infirmary, Leeds LS1 3EX.


Patients with varying degrees of acne, acne-free adult controls and samples of cord blood were investigated for cell mediated immunity to P. acnes using a leukocyte migration inhibition test. Despite the fact that the mean migration index tended to decrease with acne severity, only the patients with severe acne showed cell-mediated immunity. It is suggested that when cellular immunity arises it is a late event which may contribute to inflammation but is probably not a factor in its initiation.