A preliminary report of part of this work was presented at the 68th Annual Meeting of the International Academy of Pathology, San Francisco, California (Uitto, Santa-Cruz & Eisen, 1979).
Familial cutaneous collagenoma: genetic studies on a family*
Article first published online: 29 JUL 2006
British Journal of Dermatology
Volume 101, Issue 2, pages 185–195, August 1979
How to Cite
UITTO, J., SANTA-CRUZ, D. J. and EISEN, A. Z. (1979), Familial cutaneous collagenoma: genetic studies on a family. British Journal of Dermatology, 101: 185–195. doi: 10.1111/j.1365-2133.1979.tb05606.x
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
- Accepted for publication 21 November 1978
Familial cutaneous collagenoma is an inherited condition characterized by the presence of multiple dermal nodules symmetrically distributed on the trunk and upper arms. In this study, six patients, the proband, his four siblings and a niece, representing a kindred of fifty-two subjects, were examined for aymptomatic cutaneous nodules mainly on the back and chest. The individual lesions varying from a few millimetres to several centimetres in size, were indurated, and showed minimal epidermal changes. Histologically, the nodules were characterized by an excessive accumulation of dense, coarse collagen fibres in the dermis. The elastic fibres appeared diminished in number, and in some areas they were abnormally thin and fragmented. The lesions, therefore, were connective tissue naevi of the collagen type. On the basis of the family history and histological observations the patients were diagnosed as having familial cutaneous collagenoma. Examination of the family pedigree indicated that the dermal nodules in familial cutaneous collagenoma were inherited in an autosomal dominant pattern. It was also observed that the lesions had an onset at the age of 15 to 19 years, and their number increased significantly during pregnancy. It is conceivable that familial cutaneous collagenoma is an inherited condition whose expression may be under a hormonal control.