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Bleomycin-induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma
Article first published online: 29 JUL 2006
British Journal of Dermatology
Volume 108, Issue 6, pages 679–686, June 1983
How to Cite
MOUNTZ, J.D., MINOR, M.B.DOWNS., TURNER, R., THOMAS, M.B., RICHARDS, F. and PISKO, E. (1983), Bleomycin-induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma. British Journal of Dermatology, 108: 679–686. doi: 10.1111/j.1365-2133.1983.tb01080.x
Presented in part at the meeting of the Southern section, AFCR, New Orleans, LA, 25 January 1980 and at the ARA National Meeting, Atlanta, GA, 30 May 1980, U.S.A.
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
- Accepted for publication 26 October 1982
Rats injected with bleomycin over a 58-week period developed weight loss, alopecia, hyperpigmentation, skin thickening and skin tautness when compared with saline-injected control animals. The only significant abnormality in laboratory blood tests was an increased sedimentation rate in the bleomycin-treated rats compared with controls. Histological examination of dorsal skin showed atrophied sebaceous glands and increased collagen fibres, with diameters ranging from 37·5 to 75 nm as compared with 72·5 to 100 nm in control animals. Chronic bleomycin exposure produces clinical, histological and ultrastructural skin changes similar to those found in human progressive systemic sclerosis (scleroderma).