Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins
Article first published online: 29 JUL 2006
British Journal of Dermatology
Volume 117, Issue 1, pages 11–19, July 1987
How to Cite
SCHALIN-KARRILA, M., MATTILA, L., JANSEN, C.T. and UOTILA, P. (1987), Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. British Journal of Dermatology, 117: 11–19. doi: 10.1111/j.1365-2133.1987.tb04085.x
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
- Accepted for publication 27 November 1986
In a double-blind trial patients with atopic eczema received either oral evening primrose oil (EPO) (n= 14) or placebo (n= 11) for 12 weeks. In the EPO group a statistically significant improvement was observed in the overall severity and grade of inflammation and in the percentage of the body surface involved by eczema as well as in dryness and itch. Patients in the placebo group showed a significant reduction in inflammation. The patients receiving EPO showed a significantly greater reduction in inflammation than those receiving placebo.
Evening primrose oil caused a significant rise in the amount of dihomogammatinolenic acid in the plasma phospholipid fatty acids. Plasma levels of TXB2, 6-keto-PGF1, and PGE1, and the amount of TXB2 released into serum during clotting were not altered by evening primrose oil.