Genetic control of sebum excretion and acne—a twin study


Dr S. Walton, Department of Dermatology, Hull Royal Infirmary, Anlaby Road, Hull, N. Humberside, HU3 2JZ, U.K.


Sebum excretion and acne grades were measured in 20 pairs each of identical and non-identical like-sex twins. The identical twins had virtually identical rates of sebum excretion (P > 0·05), but they had a significantly different degree of acne severity (P < 0·01). The non-identical twins had significantly different sebum excretion rates (P > 0·01) and acne grades (P < 0·01). These findings suggest that sebum excretion is under genetic control and the development of clinical lesions is modified by environmental factors.