Acanthosis nigricans, insulin resistance and cutaneous virilism

  1. J.H. EARTH1,*,
  2. L.L. NG2,
  3. F. WOJNAROWSKA1,
  4. R.P.R. DAWBER1

Article first published online: 29 JUL 2006

DOI: 10.1111/j.1365-2133.1988.tb02561.x

Issue

British Journal of Dermatology

British Journal of Dermatology

Volume 118, Issue 5, pages 613–619, May 1988

Additional Information

How to Cite

EARTH, J., NG, L., WOJNAROWSKA, F. and DAWBER, R. (1988), Acanthosis nigricans, insulin resistance and cutaneous virilism. British Journal of Dermatology, 118: 613–619. doi: 10.1111/j.1365-2133.1988.tb02561.x

Author Information

  1. 1

    Department of Dermatology, The Slade Hospital, Oxford, U.K.

  2. 2

    Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, Oxford, U.K.

* Dr J.H.Barth, Departmem of Dermatology, The Slade Hospital, Oxford 0X3 yJH, U.K.

Publication History

  1. Issue published online: 29 JUL 2006
  2. Article first published online: 29 JUL 2006
  3. Accepted for publication 26 November 1987

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SUMMARY

Thirteen patients with the syndrome of acanthosis nigricans and insulin resistance are described. They all had a combination of dermatoscs related to hyperandrogenism (cutaneous virilism): hirsuties (II), acne vulgaris (6), hidradenitis suppurativa (5) and androgenic alopecia (4). In addition, 9 out of 13 had keratosis pilaris. The patients had raised fasting plasma insulin levels compared with matched normal controls (P·0–01) and increased insulin resistance (P·0–02). Insulin resistance correlated with total serum testosterone (rs= 0–65; P).

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