Presented in part at the American Dermatological Association meeting in St. Moritz, Switzerland, 28 June-2 July 1988.
Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasis
Article first published online: 29 JUL 2006
British Journal of Dermatology
Volume 120, Issue 6, pages 801–807, June 1989
How to Cite
GUPTA, A.K., ELLIS, C.N., TELLNER, D.C., ANDERSON, T.F. and VOORHEES, J.J. (1989), Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasis. British Journal of Dermatology, 120: 801–807. doi: 10.1111/j.1365-2133.1989.tb01378.x
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
- Accepted for publication 9 December 1988
Since eicosanoids have been implicated in the pathogenesis of psoriasis, less potent eicosanoid mediators derived from fish oil might improve psoriasis. Using a double-blind, randomized, parallel design, 18 patients with stable, plaque psoriasis received capsules of either fish oil or identical-appearing placebo olive oil for 15 weeks, with concomitant sub-erythemal UVB in weeks 3 to 11. At the conclusion of phototherapy, and 4 weeks later, patients in the fish oil group had a greater decrease in the total body surface area of psoriasis and more improvement compared to patients in the olive oil group. The improvement in the fish oil group was statistically significantly greater for all parameters compared to the change in the olive oil group. The apparent safety and general health-promoting features of fish oil could provide an ideal adjunctive therapy for psoriasis.