Society in June 1990 (Scot Med J 1991; 36: 29).
Idiopathic CD4+ lymphocytopenia associated with chronic pruritic papules
Article first published online: 29 JUL 2006
British Journal of Dermatology
Volume 131, Issue 3, pages 371–375, September 1994
How to Cite
PWAKEEL, R.A., URBANIAK, S.J., ARMSTRONG, S.S., SEWELL, H.F., HERRIOT, R., KERNOHAN, N. and WHITE, M.I. (1994), Idiopathic CD4+ lymphocytopenia associated with chronic pruritic papules. British Journal of Dermatology, 131: 371–375. doi: 10.1111/j.1365-2133.1994.tb08527.x
This case was presented at a meeting of the Scottish Dermatological
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
- Accepted for publication 10 February 1994
This is a case report and family study of a 65-year-old man with chronic prurigo lesions, in whom we demonstrated a selective deficiency of circulating T-helper/inducer lymphocytes (CD4+), in the absence of any apparent predisposing disease. He is seronegative for human immunodeficiency virus (HIV types 1 and 2) and human T-cell lymphotropic virus (HTLV-I and HTLV-II), and fulfils the criteria for the syndrome of idiopathic CD4+ Tlymphocytopenia. He has an atopic diathesis, has had a severe adult chickenpos infection, chronic staphylococcal infections, tinea pedis and recalcitrant warts. He has also suffered from respiratory infections, for which no specific aetiological agent has been identified. His peripheral total lymphocyte count has been persistently abnormal since it was first measured in 1969. He has a marked CD4+ T-cell lymphocytopenia. His son, who does not have any skin disorder, has a low CD4+ T-cell count.