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Quantifying systemic absorption of topical hydrocortisone in erythroderma
Article first published online: 29 JUL 2006
DOI: 10.1111/j.1365-2133.1995.tb02668.x
1365-2133/asset/cover.gif?v=1&s=413074e1e506a67a21dcc4e2de9ff9b6ce256d16 "British Journal of Dermatology")
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How to Cite
AALTO-KORTE, K. and TURPEINEN, M. (1995), Quantifying systemic absorption of topical hydrocortisone in erythroderma. British Journal of Dermatology, 133: 403–408. doi: 10.1111/j.1365-2133.1995.tb02668.x
Publication History
- Issue published online: 29 JUL 2006
- Article first published online: 29 JUL 2006
- Acepted for publication 26 October 1994
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Summary
The systemic absorption of topical hydrocortisone (HC) was quantified in seven patients with erythroderma, using the ratio of the areas under the curves for plasma concentration vs. time, following topical and intravenous administration. Over a period of 24 h. 19–93 mg of HC was absorbed systemically, corresponding to 4–19% of the total topical dose of 500 mg. Thus, topical HC therapy of erythroderma is accompanied by a pharmacologically significant systemic dose.