Epstein–Barr virus-associated lymphoproliferative lesions presenting as a hydroa vacciniforme-like eruption: an analysis of six cases
Article first published online: 6 AUG 2004
British Journal of Dermatology
Volume 151, Issue 2, pages 372–380, August 2004
How to Cite
Cho, K.-H., Lee, S.-H., Kim, C.-W., Jeon, Y.-K., Kwon, I.-H., Cho, Y.-J., Lee, S.-K., Suh, D.-H., Chung, J.-H., Yoon, T.-Y. and Lee, S.-J. (2004), Epstein–Barr virus-associated lymphoproliferative lesions presenting as a hydroa vacciniforme-like eruption: an analysis of six cases. British Journal of Dermatology, 151: 372–380. doi: 10.1111/j.1365-2133.2004.06038.x
- Issue published online: 6 AUG 2004
- Article first published online: 6 AUG 2004
- Accepted for publication 11 December 2003
- Epstein–Barr virus;
- hydroa vacciniforme;
Background There are many reports of patients with a severe hydroa vacciniforme (HV)-like eruption in which cutaneous lesions occur in both sun-exposed and non-exposed areas, unlike in true HV. Several patients have died from a malignant haematological neoplasm. In most cases, a latent Epstein–Barr virus (EBV) infection has been detected in the skin lesions.
Objectives To describe the clinical and laboratory features of six additional patients with an EBV-associated HV-like eruption.
Methods The clinical, histological and immunohistochemical features were reviewed. T-cell receptor γ gene rearrangements were studied using polymerase chain reaction (PCR) and heteroduplex analysis. In-situ hybridization was performed to detect mRNA for EBV in skin biopsy specimens. PCR was performed to screen for EBV infection in the skin lesions of three patients and blood of two patients. Photoprovocation with repeated ultraviolet (UV) A exposure was performed in three patients.
Results The severity of the skin lesions and the clinical course varied among the patients. Skin lesions were induced by repeated UVA exposure in three patients and a latent EBV infection was demonstrated in the photoprovoked lesions.
Conclusions Three different clinical courses were found in six patients with an HV-like eruption associated with chronic EBV infection: (i) spontaneous remission; (ii) clearing after photoprotection; and (iii) continuous recurrence irrespective of sun exposure. It is possible that there are two patterns of HV-like eruption associated with chronic EBV infection. One is characterized by recurrent necrotic papulovesicles of the face and the other by nodules and facial swelling. It was demonstrated that the skin lesions could be triggered by repeated UVA exposure in the patients showing recurrent necrotic papulovesicles of the face.