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Biological therapies in the systemic management of psoriasis: International Consensus Conference

Authors

  • W. Sterry,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • J. Barker,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • W.-H. Boehncke,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • J.D. Bos,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • S. Chimenti,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • E. Christophers,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • M. De La Brassinne,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • C. Ferrandiz,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • C. Griffiths,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • A. Katsambas,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • K. Kragballe,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • C. Lynde,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • A. Menter,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • J.-P. Ortonne,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • K. Papp,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • J. Prinz,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • B. Rzany,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • J. Ronnevig,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • J.-H. Saurat,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • M. Stahle,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • F.M. Stengel,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • P. Van De Kerkhof,

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • J. Voorhees

    1. Department of Dermatology and Allergy, University Hospital Charité, Schumannstr. 20/21, D-10117 Berlin, Germany
      *St John's Institute of Dermatology, St Thomas' Hospital, London, UK
      †Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
      ‡Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
      §Clinica Dermatologica, Università degli Studi di Roma ‘Tor Vergata’, Rome, Italy
      ¶University of Kiel, Kiel, Germany
      **University Hospital Liège, Liège, Belgium
      ††Hospital Universitario Germans Trias i Pujol, Barcelona, Spain**University of Manchester, Manchester, UK
      §§University of Athens Medical School, Athens, Greece
      ¶¶Aarhus University Hospital, Aarhus, Denmark
      ***Lynde Centre for Dermatology, Toronto, Ontario, Canada
      †††Texas Dermatology Research Institute, Dallas, TX, U.S.A.
      ‡‡‡Nice University, Nice, France
      §§§University of Western Ontario, London, Ontario, Canada
      ¶¶¶University of Munich, Munich, Germany
      ****Department of Dermatology, The National Hospital, Oslo, Norway
      ††††Hôpital Cantonal Universitaire, Geneva, Switzerland
      ‡‡‡‡Karolinska University Hospital, Solna, Stockholm, Sweden
      §§§§University Institute Cemic Dermatology, Buenos Aires, Argentina
      ¶¶¶¶University Hospital Nijmegen, Nijmegen, the Netherlands
      *****University of Michigan Medical School, Ann Arbor, MI, U.S.A.
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  • For conflicts of interest see the Acknowledgements section.

Wolfram Sterry
E-mail: wolfram.sterry@charite.de

Summary

Psoriasis is a chronic, immune-mediated disorder that usually requires long-term treatment for control. Approximately 25% of patients have moderate to severe disease and require phototherapy, systemic therapy or both. Despite the availability of numerous therapeutic options, the long-term management of psoriasis can be complicated by treatment-related limitations. With advances in molecular research and technology, several biological therapies are in various stages of development and approval for psoriasis. Biological therapies are designed to modulate key steps in the pathogenesis of psoriasis. Collectively, biologicals have been evaluated in thousands of patients with psoriasis and have demonstrated significant benefit with favourable safety and tolerability profiles. The limitations of current psoriasis therapies, the value of biological therapies for psoriasis, and guidance regarding the incorporation of biological therapies into clinical practice are discussed.

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