Conflicts of interest: The authors have no conflict of interest to disclose.
A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5-flucytosine
Article first published online: 17 MAR 2005
British Journal of Dermatology
Volume 152, Issue 3, pages 560–564, March 2005
How to Cite
Park, S.-G., Oh, S.-H., Suh, S.-B., Lee, K.-H. and Chung, K.-Y. (2005), A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5-flucytosine. British Journal of Dermatology, 152: 560–564. doi: 10.1111/j.1365-2133.2005.06424.x
- Issue published online: 17 MAR 2005
- Article first published online: 17 MAR 2005
- Accepted for publication 28 September 2004
- amphotericin B;
- Phialophora verrucosa;
- unexposed area
Chromoblastomycosis is a cutaneous and subcutaneous mycotic disease caused by the dematiaceous (black) fungi. Five species of fungi are known generally to be the cause: Fonsecaea pedrosoi, Phialophora verrucosa, Cladosporium carrionii, F. compacta and Rhinocladiella cerphilum. In infected tissue they can appear as pigmented sclerotic bodies, commonly called ‘copper pennies’, which are pathognomonic of chromoblastomycosis. The infection usually occurs through traumatic skin inoculation, with the majority of lesions occurring on the feet and legs of outdoor workers. We report a patient in whom the lesions had begun on the right breast, which is an unexposed area, without a history of trauma. A uniform, reliable treatment does not exist but our patient was mycologically cured with the use of amphotericin B and the subsequent combination of 5-flucytosine and itraconazole.