Conflicts of interest: None declared.
Molecular aetiology and pathogenesis of basal cell carcinoma
Version of Record online: 8 JUN 2005
British Journal of Dermatology
Volume 152, Issue 6, pages 1108–1124, June 2005
How to Cite
Tilli, C.M.L.J., Van Steensel, M.A.M., Krekels, G.A.M., Neumann, H.A.M. and Ramaekers, F.C.S. (2005), Molecular aetiology and pathogenesis of basal cell carcinoma. British Journal of Dermatology, 152: 1108–1124. doi: 10.1111/j.1365-2133.2005.06587.x
- Issue online: 8 JUN 2005
- Version of Record online: 8 JUN 2005
- Accepted for publication 12 August 2004
- basal cell carcinoma;
- cell signalling;
- epidermal stem cells;
Recent insights into the cell biology of the epidermis and its appendages are transforming our understanding of the pathogenesis of basal cell carcinoma (BCC). The significant progress that has been made warrants a comprehensive review of the molecular and cellular pathology of BCC. The items addressed include environmental and genetic risk factors, the biology of the putative precursor cell(s), and the contribution of aberrations in processes such as apoptosis, cell proliferation, differentiation and signalling to carcinogenesis. Furthermore, established and novel treatment modalities are discussed with particular attention to future biological approaches.