Conflicts of interest: None declared.
Chronic obesity lymphoedematous mucinosis: three cases of pretibial mucinosis in obese patients with pitting oedema
Version of Record online: 11 SEP 2005
British Journal of Dermatology
Volume 154, Issue 1, pages 157–161, December 2006
How to Cite
Tokuda, Y., Kawachi, S., Murata, H. and Saida, T. (2006), Chronic obesity lymphoedematous mucinosis: three cases of pretibial mucinosis in obese patients with pitting oedema. British Journal of Dermatology, 154: 157–161. doi: 10.1111/j.1365-2133.2005.06901.x
- Issue online: 11 SEP 2005
- Version of Record online: 11 SEP 2005
- Accepted for publication 20 May 2005
- chronic obesity lymphoedematous mucinosis;
- pitting oedema;
- pretibial mucinosis;
- pretibial myxoedema
Pretibial mucin deposition on the shins is known as pretibial myxoedema. We report three patients with pretibial mucinosis without thyroid disease. The patients were characterized clinically by morbid obesity and bilateral lower extremity pitting oedema with gradual and painless onset, and that did not involve the feet and ankles. Vesicles, semitranslucent papules or a woody plaque were found on the shins. Histologically, patients showed characteristic features of epidermal atrophy with effacement of the rete ridge pattern, separation of collagen bundles associated with oedema with stellate to linear fibroblasts, upward-running increased capillary and small vessels with haemosiderin deposition, and mucin deposition at the superficial papillary dermis and around the vessels. We propose that the present cases of ‘chronic obesity lymphoedematous mucinosis’ belong to the clinical entity of pretibial mucinosis.