Conflicts of interest: None declared.
Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin
Article first published online: 10 OCT 2005
British Journal of Dermatology
Volume 154, Issue 2, pages 345–352, February 2006
How to Cite
Campalani, E., Allen, M.H., Fairhurst, D., Young, H.S., Mendonca, C.O., Burden, A.D., Griffiths, C.E.M., Crook, M.A., Barker, J.N.W.N. and Smith, C.H. (2006), Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. British Journal of Dermatology, 154: 345–352. doi: 10.1111/j.1365-2133.2005.06950.x
- Issue published online: 10 OCT 2005
- Article first published online: 10 OCT 2005
- Accepted for publication 1 March 2005
- apolipoprotein E;
Background Psoriasis is associated with abnormal plasma lipid metabolism and a high frequency of cardiovascular events. Increased lipid levels are also seen in patients with psoriasis treated with acitretin. Apolipoprotein E (ApoE) variants have been linked to hypertriglyceridaemia and hypercholesterolaemia in normal individuals. Two coding single nucleotide polymorphisms at +3937 and +4075 define the three common ApoE alleles e2, e3 and e4.
Objectives To test the hypothesis that particular ApoE polymorphism(s) are associated with psoriasis and that specific ApoE allelic variant(s) may be a marker for predicting disease response to acitretin.
Methods DNA was genotyped for ApoE polymorphisms using a radioactive hybridization technique in cohorts of patients with psoriasis, including patients with chronic plaque psoriasis (CPP, n = 212), guttate psoriasis (GP, n = 94), palmoplantar pustulosis (PPP, n = 101), controls (n = 137), acitretin responders (n =106) and acitretin nonresponders (n = 84).
Results The frequency of the e4 allele (+3937C/+4075C) was significantly higher in patients with CPP and GP than in controls (P = 0·008 and P = 0·02, respectively). There was no significant difference in allele frequencies between patients with PPP and controls. Allelic distribution was similar in acitretin responders and nonresponders.
Conclusions These data demonstrate an association between the Apo e4 allele and CPP and GP, suggesting a possible pathogenic role for ApoE in psoriasis. Our results do not support a link between disease response to acitretin and the e2, e3 or e4 allelic variants of ApoE.