Conflicts of interest None declared.
Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects
Article first published online: 8 MAY 2006
British Journal of Dermatology
Volume 155, Issue 1, pages 104–109, July 2006
How to Cite
Jakasa, I., De Jongh, C.M., Verberk, M.M., Bos, J.D. and Kežić, S. (2006), Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects. British Journal of Dermatology, 155: 104–109. doi: 10.1111/j.1365-2133.2006.07319.x
- Issue published online: 8 MAY 2006
- Article first published online: 8 MAY 2006
- Accepted for publication 30 December 2005
- atopic dermatitis;
- percutaneous penetration;
- sodium lauryl sulphate;
- tape stripping
Background Involved regions of the skin in patients with atopic dermatitis (AD) have been shown to have higher transepidermal water loss (TEWL), indicating a compromised skin barrier. Whether uninvolved skin also has diminished barrier characteristics is controversial.
Objectives To study the penetration of sodium lauryl sulphate (SLS) into uninvolved skin of patients with AD compared with the skin of control subjects.
Methods Percutaneous penetration was assessed using the tape stripping technique on the stratum corneum (SC). Twenty patients with AD and 20 healthy subjects were exposed to 1% SLS for 4 h on the mid-volar forearm. After the end of exposure the SC was removed by adhesive tape. The amount of SLS was determined in each consecutive strip. Fick's second law of diffusion was used to deduce the diffusivity and the partition coefficient of SLS between water and the SC.
Results The SC thickness was similar in both groups; however, the TEWL was higher in patients with AD compared with that of the control group (mean ± SD 8·4 ± 4·3 and 6·3 ± 2·0 g m−2 h−1, respectively). There was a correlation between SC thickness and TEWL in control subjects but no correlation was found in patients with AD. The diffusivity of SLS through uninvolved AD skin was higher compared with normal skin (mean ± SD 12·7 ± 5·8 × 10−9 and 6·2 ± 3·0 × 10−9 cm−2 h−1, respectively), while the partition coefficient between SC and water was lower (mean ± SD 137 ± 64 and 196 ± 107, respectively).
Conclusions The results show a different penetration profile of SLS into the SC of patients with AD compared with control subjects. This indicates that even noninvolved skin in patients with AD has altered barrier characteristics, emphasizing the importance of skin protection and prevention of skin contact with chemicals.