Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis

Authors

  • R. Fölster-Holst,

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • F. Müller,

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • N. Schnopp,

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • D. Abeck,

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • I. Kreiselmaier,

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • T. Lenz,

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • U. Von Rüden,

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • J. Schrezenmeir,

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • E. Christophers,

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • M. Weichenthal

    1. Department of Dermatology, University of Kiel, Schittenhelmstr. 7, D-24105 Kiel, Germany
      *Department of Dermatology, Technical University Munich, Munich, Germany
      †Statistical Consulting, Mannheim, Germany
      ‡Federal Centre for Health Education, Cologne, Germany
      §Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, Kiel, Germany
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  • Conflicts of interest
    None declared.

Regina Fölster-Holst.
E-mail: rfoelsterholst@dermatology.uni-kiel.de

Summary

Background  A reduction of symptoms of atopic dermatitis (AD) in small infants by the administration of Lactobacillus rhamnosus has been reported in a few studies. One study with older children and adolescents failed to show any effect.

Objectives  We conducted a prospective study to reassess the efficacy of orally administered L. rhamnosus strain GG (LGG) in infants with AD.

Methods  In a randomized, double-blind, placebo-controlled study, 54 infants aged 1–55 months with moderate to severe AD were randomized to daily 10 × 109 colony-forming units of LGG or to placebo during an 8-week intervention phase. Emollients, class I–II topical corticosteroids and antihistamines were permitted.

Results  The treatment with LGG was well tolerated. At the end of treatment there were no significant differences between the groups with respect to clinical symptoms (SCORAD, pruritus, sleep loss), the use of topical corticosteroids and antihistamines, immunological parameters, or health-related quality of life of the parents.

Conclusions  Our results could not confirm LGG as an effective treatment of AD in infancy.

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