Conflicts of interest None declared.
Psoriasis: a possible risk factor for development of coronary artery calcification
Article first published online: 18 OCT 2006
British Journal of Dermatology
Volume 156, Issue 2, pages 271–276, February 2007
How to Cite
Ludwig, R.J., Herzog, C., Rostock, A., Ochsendorf, F.R., Zollner, T.M., Thaci, D., Kaufmann, R., Vogl, T.J. and Boehncke, W.-H. (2007), Psoriasis: a possible risk factor for development of coronary artery calcification. British Journal of Dermatology, 156: 271–276. doi: 10.1111/j.1365-2133.2006.07562.x
R.J.L. and C.H. contributed equally to this study.
- Issue published online: 18 OCT 2006
- Article first published online: 18 OCT 2006
- Accepted for publication 15 June 2006
- cardiovascular diseases;
- spiral computed tomography
Background Psoriasis is a chronic inflammatory skin disorder affecting about 2% of white-skinned individuals. Epidemiological data on the prevalence and degree of coronary artery calcification (CAC) as an indicator for cardiovascular diseases in patients with psoriasis are contradictory.
Objectives To study the prevalence and degree of CAC as an indicator for cardiovascular diseases in 32 patients with psoriasis matched for age, sex and risk factors to an equally sized control population.
Methods Noncontrast-enhanced 16-row spiral computed tomography was performed in patients and controls.
Results We found a significantly increased prevalence (59·4% vs. 28·1%, P = 0·015) and severity (CAC score according to Agatston 3·7 vs. 0·0, P = 0·019) of CAC in patients with psoriasis. Multiple linear regression calculations identified psoriasis as a likely independent risk factor for CAC.
Conclusions Our results point towards the potentially systemic nature of the inflammatory processes underlying the pathogenesis of psoriasis, which may therefore be considered a potentially severe systemic disease.