Conflicts of interest None declared.
Association between cutaneous melanoma, Breslow thickness and vitamin D receptor BsmI polymorphism
Article first published online: 6 DEC 2006
British Journal of Dermatology
Volume 156, Issue 2, pages 277–282, February 2007
How to Cite
Santonocito, C., Capizzi, R., Concolino, P., Lavieri, M.M., Paradisi, A., Gentileschi, S., Torti, E., Rutella, S., Rocchetti, S., Di Carlo, A., Di Stasio, E., Ameglio, F., Zuppi, C. and Capoluongo, E. (2007), Association between cutaneous melanoma, Breslow thickness and vitamin D receptor BsmI polymorphism. British Journal of Dermatology, 156: 277–282. doi: 10.1111/j.1365-2133.2006.07620.x
- Issue published online: 6 DEC 2006
- Article first published online: 6 DEC 2006
- Accepted for publication 23 July 2006
- vitamin D receptor
Summary Background Literature data report an association between some vitamin D receptor (VDR) polymorphisms and different kinds of tumours, including malignant melanoma (MM). Only three VDR polymorphisms (FokI, TaqI and A-1012G) have been investigated in association with the presence of cutaneous MM or the development of metastases.
Objectives The present paper analyses for the first time the association between BsmI polymorphism and MM prevalence together with Breslow thickness. In addition, the FokI single nucleotide polymorphism was also determined.
Methods One hundred and one patients with MM and 101 healthy donors matched for age and sex were enrolled. Molecular VDR typing was performed by means of restriction fragment length polymorphism analysis.
Results All cases and controls were in Hardy–Weinberg equilibrium for BsmI, FokI and A-1012G. Significant associations were found between the BsmI bb genotype frequency and MM (P = 0·02) along with Breslow thickness (P = 0·001). This same behaviour was not observed for the FokI or A-1012G polymorphisms. Multivariate logistic regression analysis confirmed these significant results after correction for age, gender, skin type and MM localization.
Conclusions Although the biological meaning of the effects exerted by BsmI polymorphism is still under debate, the statistical association found in the present study suggests that further work should be done to verify this variant as a possible risk marker for MM and its aggressiveness, also considering that the real association may be due to other unknown genes linked to the BsmI b allele.