Conflicts of interest None declared.
Use of oral glycopyrronium bromide in hyperhidrosis
Article first published online: 25 APR 2007
British Journal of Dermatology
Volume 157, Issue 1, pages 118–121, July 2007
How to Cite
Bajaj, V. and Langtry, J.A.A. (2007), Use of oral glycopyrronium bromide in hyperhidrosis. British Journal of Dermatology, 157: 118–121. doi: 10.1111/j.1365-2133.2007.07884.x
This study was presented as a poster at the British Association of Dermatologists Annual Conference in Manchester, July 2006.
- Issue published online: 15 JUN 2007
- Article first published online: 25 APR 2007
- Accepted for publication 20 December 2006
- glycopyrronium bromide;
Background Idiopathic hyperhidrosis may be a disabling condition causing emotional stress and negative impact on a patient's quality of life. Oral anticholinergics are one of the treatments available. There are few published data on the use of the anticholinergic drug glycopyrronium bromide (glycopyrrolate) given orally in the treatment of hyperhidrosis.
Objectives To report a retrospective analysis describing the treatment responses, doses and side-effects of oral glycopyrrolate in the treatment of idiopathic hyperhidrosis.
Methods Review of case notes in a series of 24 patients, nine with generalized and 15 with localized hyperhidrosis.
Results Fifteen of 19 evaluable patients (79%) responded to oral glycopyrrolate. However, treatment was limited by side-effects in around one third of patients.
Conclusions A prospective clinical study to compare the efficacy and side-effects of oral anticholinergics is warranted.