Conflicts of interest None declared.
Photoageing: mechanism, prevention and therapy
Article first published online: 17 AUG 2007
British Journal of Dermatology
Volume 157, Issue 5, pages 874–887, November 2007
How to Cite
Yaar, M. and Gilchrest, B.A. (2007), Photoageing: mechanism, prevention and therapy. British Journal of Dermatology, 157: 874–887. doi: 10.1111/j.1365-2133.2007.08108.x
- Issue published online: 17 AUG 2007
- Article first published online: 17 AUG 2007
- Accepted for publication 16 April 2007
- extrinsic ageing;
- premature skin ageing;
- ultraviolet photodamage
Photoageing is the superposition of chronic ultraviolet (UV)-induced damage on intrinsic ageing and accounts for most age-associated changes in skin appearance. It is triggered by receptor-initiated signalling, mitochondrial damage, protein oxidation and telomere-based DNA damage responses. Photodamaged skin displays variable epidermal thickness, dermal elastosis, decreased/fragmented collagen, increased matrix-degrading metalloproteinases, inflammatory infiltrates and vessel ectasia. The development of cosmetically pleasing sunscreens that protect against both UVA and UVB irradiation as well as products such as tretinoin that antagonize the UV signalling pathways leading to photoageing are major steps forward in preventing and reversing photoageing. Improved understanding of the skin’s innate UV protective mechanisms has also given rise to several novel treatment concepts that promise to revolutionize this field within the coming decade. Such advances should not only allow for the improved appearance of skin in middle age and beyond, but also greatly reduce the accompanying burden of skin cancer.