Conflicts of interest one declared.
Filaggrin null alleles are not associated with hand eczema or contact allergy
Article first published online: 26 OCT 2007
British Journal of Dermatology
Volume 157, Issue 6, pages 1199–1204, December 2007
How to Cite
Lerbaek, A., Bisgaard, H., Agner, T., Ohm Kyvik, K., Palmer, C.N.A. and Menné, T. (2007), Filaggrin null alleles are not associated with hand eczema or contact allergy. British Journal of Dermatology, 157: 1199–1204. doi: 10.1111/j.1365-2133.2007.08252.x
- Issue published online: 26 OCT 2007
- Article first published online: 26 OCT 2007
- Accepted for publication 31 July 2007
- atopic dermatitis;
- contact allergy;
- hand eczema
Background The filaggrin protein is a key component of stratum corneum and homo- or heterozygotes for the filaggrin variant alleles R501X and 2282del4 have varying degrees of impaired skin barrier. The variant alleles have repeatedly been shown to be associated with atopic dermatitis. Any possible association with hand eczema or contact allergy are unexplored.
Objectives To explore associations between the variant alleles, hand eczema, contact allergy and atopic dermatitis.
Methods In total, 183 adult individuals participated in a clinical examination of the hands, patch testing and filaggrin genotyping. Children without any evidence of atopic dermatitis from the Copenhagen Prospective Study on Asthma in Childhood (COPSAC) study were used as controls. The χ2 test was used for comparison of allele frequencies.
Results The majority (73%) had hand eczema, 25% had contact allergy and 14% had a diagnosis of atopic dermatitis. The association between atopic dermatitis and the filaggrin variant alleles was confirmed (odds ratio 3·5, P = 0·015). Allele frequencies in individuals with hand eczema or contact allergy were not statistically significantly increased.
Conclusion There is no association between the variant alleles and hand eczema or contact allergy.