Conflicts of interest: ES acts as a consultant to Meda Pharma. TM and EC declare no conflicts of interest.
Immune response profiles in human skin
Article first published online: 7 DEC 2007
British Journal of Dermatology
Volume 157, Issue Supplement s2, pages 1–7, December 2007
How to Cite
Meyer, T., Stockfleth, E. and Christophers, E. (2007), Immune response profiles in human skin. British Journal of Dermatology, 157: 1–7. doi: 10.1111/j.1365-2133.2007.08264.x
- Issue published online: 7 DEC 2007
- Article first published online: 7 DEC 2007
- Accepted for publication 4 September 2007
- adaptive immunity;
- epithelial defense;
- innate immunity;
- TH17 cell;
- toll-like receptor
In addition to the function as a physical barrier human skin has been shown to be an important immune organ displaying various defense mechanisms, which can be divided into three major functional compartiments: (i) Epithelial defense, which is characterized by antimicrobial peptides and proteins (AP) and which can be induced in inflammatory lesions but also in the absence of inflammation. (ii) Innate-inflammatory immunity, which involves recognition of microbial compounds by particular receptors like Toll-like receptors (TLR) and subsequent activation of signalling pathways resulting in expression of pro-inflammatory cytokines and interferons, as well as genes of adaptive immunity. Interferon α (IFNα) produced by plasmacytoid dendritic cells (DC) may stimulate myeloid DC to produce IL-12 resulting in classical T-cell activation or to produce IL-23 activating IL-17 producing T-cells (IL-23/IL-17 pathway). (iii) Adaptive immunity, which is based on antigen presenting cells, T-cells and B-cells and which is characterized by specificity and memory. In contrast to epithelial defense and innate-inflammatory immunity, adaptive immune functions provide slowly reacting protection. Recent improvements of our knowledge of dysregulated immune pathways associated with inflammatory skin diseases represent an important basis of novel immunomodulatory treatment modalities.