Conflicts of interest A.S., J.J.J., J.L. and P.S. have now founded a company (Repolar Ltd) for developing the resin salve as a commercial product. P.S. is a shareholder and scientific advisor of Biohit Plc, a company that markets and develops laboratory equipment and tests. There are no other conflicts of interest.
Beneficial effect of resin salve in treatment of severe pressure ulcers: a prospective, randomized and controlled multicentre trial
Version of Record online: 18 FEB 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 158, Issue 5, pages 1055–1062, May 2008
How to Cite
Sipponen, A., Jokinen, J.J., Sipponen, P., Papp, A., Sarna, S. and Lohi, J. (2008), Beneficial effect of resin salve in treatment of severe pressure ulcers: a prospective, randomized and controlled multicentre trial. British Journal of Dermatology, 158: 1055–1062. doi: 10.1111/j.1365-2133.2008.08461.x
A.S. and J.J.J. contributed equally to this study.
- Issue online: 18 FEB 2008
- Version of Record online: 18 FEB 2008
- Accepted for publication 9 December 2007
- hydrofibre dressing;
- methicillin-resistant Staphylococcus aureus;
- pressure ulcer;
- randomized controlled trial;
- resin salve;
- wound healing
Background Resin salve of the Norway spruce (Picea abies) has been used in folk medicine to heal wounds and infections.
Objectives To study its clinical effectiveness in the treatment of pressure ulcers of the skin.
Methods A prospective, randomized, controlled multicentre trial involving 37 patients with grade II–IV pressure ulcers in 11 primary care hospitals was carried out between 2005 and 2007. The ulcers were randomly allocated to receive either resin salve or sodium carboxymethylcellulose hydrocolloid polymer treatment. The inclusion criterion was grade II–IV pressure ulcer. Exclusion criteria were a life expectancy of less than 6 months or a malignant disease. The primary outcome measure was complete healing of the ulcer within 6 months. Secondary outcome measures were partial healing of the ulcer, and successful eradication of bacterial strains cultured from the ulcers at study entry.
Results Thirteen patients of the resin group and nine patients of the control group completed the 6-month trial. All ulcers healed in 12 of the 13 patients (92%) in the resin group and in four of the nine patients (44%) in the control group (P = 0·003; power 73%). Complete healing of the ulcers over time was significantly more common in the resin group than in the control group (P = 0·013). Bacterial cultures from the ulcer area more often became negative within 1 month in the resin group.
Conclusions Traditional resin salve is significantly more effective in the treatment of infected and noninfected severe pressure ulcers than cellulose polymer gauzes.