Conflicts of interest None declared.
Topical glycopyrrolate for patients with facial hyperhidrosis
Version of Record online: 22 FEB 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 158, Issue 5, pages 1094–1097, May 2008
How to Cite
Kim, W.O., Kil, H.K., Yoon, K.B. and Yoon, D.M. (2008), Topical glycopyrrolate for patients with facial hyperhidrosis. British Journal of Dermatology, 158: 1094–1097. doi: 10.1111/j.1365-2133.2008.08476.x
- Issue online: 22 FEB 2008
- Version of Record online: 22 FEB 2008
- Accepted for publication 4 November 2007
- forehead hyperhidrosis;
- topical glycopyrrolate
Background Facial hyperhidrosis may negatively impact the quality of life. Although various conservative modalities have been suggested, the condition is not often treated successfully.
Objectives To examine whether topical glycopyrrolate could be an effective and safe treatment for facial hyperhidrosis.
Methods Twenty-five patients with facial hyperhidrosis were enrolled and treated with 2% topical glycopyrrolate on one half of the forehead while the other half of the forehead was treated with a placebo.
Results The sweat production rate of the half of the forehead treated with topical glycopyrrolate was significantly reduced to 37·6 ± 2·8 mg min−1 (mean ± SEM) compared with 102·2 ± 5·5 mg min−1 at the placebo-treated half of the forehead (P < 0·001). Patients evaluated their degree of anhidrosis as excellent in six (24%) patients, good in 16 (64%), fair in two (8%) and poor in one (4%). Twenty-four patients (96%) were partially or fully satisfied with their fair to excellent anhidrosis; only one patient (who developed a transient headache after treatment) was dissatisfied with its therapeutic effect. Only seven patients (28%) experienced recurrence within 1 day while 17 patients (68%) had recurrence within 2 days. One patient (4%) remained stable for up to 4 days.
Conclusions Topical glycopyrrolate application appears to be effective and safe for the treatment of excessive facial sweating in primary craniofacial and secondary gustatory hyperhidrosis following sympathectomy.