Conflicts of interest None declared.
Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea
Article first published online: 16 MAY 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 159, Issue 1, pages 86–90, July 2008
How to Cite
Fawzi, M.M.T., Tawfik, S.O., Eissa, A.M., El-Komy, M.H.M., Abdel-Halim, M.R.E. and Shaker, O.G. (2008), Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea. British Journal of Dermatology, 159: 86–90. doi: 10.1111/j.1365-2133.2008.08592.x
- Issue published online: 16 MAY 2008
- Article first published online: 16 MAY 2008
- Accepted for publication 11 August 2007
- growth factors;
- insulin-like growth factor-I;
Background Morphoea (scleroderma) is a chronic disorder characterized by circumscribed sclerotic plaques with the hallmark of increased fibroblast activation and fibrosis. Through its effect on connective tissue cells and immune cells, insulin-like growth factor (IGF)-I has been found to play a role in some autoimmune connective tissue diseases and has been implicated in the pathogenesis of several fibrotic disorders.
Objectives To evaluate the role of IGF-I in the pathogenesis of morphoea.
Methods The study was carried out on 15 patients with morphoea and nine healthy controls. Two 5-mm punch skin biopsies were taken from every patient (one from lesional and one from non-lesional skin) and a single biopsy was taken from the normal skin of each control. A 10-mL blood sample was also taken from each patient and control. Quantitative detection of tissue and serum levels of IGF-I was done using an enzyme-linked immunosorbent assay technique.
Results IGF-I in lesional skin was significantly higher than in non-lesional and control skin (P = 0·001 and P = 0·021, respectively). Moreover, a significantly higher level of IGF-I was detected in patient serum when compared with control serum (P < 0·001). A direct significant correlation existed between lesional and non-lesional skin level (r = 0·618, P = 0·014), and between lesional skin level and Rodnan score (r = 0·538, P = 0·039).
Conclusions Despite the small sample size, this study suggests that IGF-I plays an important role in the pathogenesis of fibrosis, characteristic of morphoea. Studies on a larger number of patients with morphoea as well as on patients with systemic sclerosis are recommended. Furthermore, therapeutic trials using IGF-I antagonist (octreotide) are highly recommended in patients with morphoea.