Conflicts of interest Prof. Dr P.C.M. van de Kerkhof has received funds for research, fees for educational events and fees for consultancy from the following companies: Schering Plough, Cellgene, Centocor, Almirall, UCB, Wyeth, Pfizer, Sofinova, Abbott, Actelion, Galderma, Novartis, Janssen Cilag, Leo Pharma, Merck Serono, Philips Lighting. Dr E.M.G.J. de Jong serves as a consultant for Biogen, Serono, Wyeth, and Abbott. Dr E.M.G.J. de Jong receives research grants from Schering Plough, Abbott, Merck Serono, Wyeth, and Centocor.
Relevance of compartmentalization of T-cell subsets for clinical improvement in psoriasis: effect of immune-targeted antipsoriatic therapies
Article first published online: 9 MAY 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 159, Issue 1, pages 91–96, July 2008
How to Cite
Van Lingen, R.G., Körver, J.E.M., Van De Kerkhof, P.C.M., Berends, M.A.M., Van Rens, D.W.A., Langewouters, A.M., Boezeman, J.B.M., Seyger, M.M.B. and De Jong, E.M.G.J. (2008), Relevance of compartmentalization of T-cell subsets for clinical improvement in psoriasis: effect of immune-targeted antipsoriatic therapies. British Journal of Dermatology, 159: 91–96. doi: 10.1111/j.1365-2133.2008.08618.x
- Issue published online: 9 MAY 2008
- Article first published online: 9 MAY 2008
- Accepted for publication 5 February 2008
- peripheral blood;
- T cells
Background Therapies targeting the T cell-mediated pathology of psoriasis have been found to achieve remarkable clinical improvement and have confirmed the crucial role of the immune system either in peripheral blood (PB) or in skin. No analyses of T-cell counts in both compartments have been conducted in order to confirm or refute the hypothesized shifts between them.
Objectives To gain more insight in the dynamics of compartmentalization of T cells between PB and lesional skin of patients with psoriasis, in response to immune-targeted antipsoriatic therapies.
Methods Eighteen patients with psoriasis received either efalizumab (n = 9) or etanercept (n = 9) for 12 weeks. Biopsies were taken for immunohistochemical analysis of T-cell subsets and simultaneously T-cell subsets were isolated from PB specimens by flow cytometry.
Results The Psoriasis Area and Severity Index declined significantly after 12 weeks of etanercept, but not for efalizumab. After treatment with efalizumab, a significantly decreased number of all T-cell subsets was found in the dermis. In the epidermis, CD4+, CD8+, CD25+, CD45RO+ and CD161+ T-cell subsets were significantly decreased. With respect to etanercept, few significant changes in T-cell subsets were found. The percentage of lymphocytes in PB was significantly elevated after efalizumab treatment regardless of responder status.
Conclusions Treatment with efalizumab establishes successful recompartmentalization of T-cell subsets with modest clinical efficacy after 12 weeks, whereas in etanercept-treated patients, a significant clinical response is no guarantee for significant changes in T-cell subsets in the different compartments. Reductions in T-cell subsets cannot be used as predictive markers for the clinical response to therapy. Interference with the studied T-cell populations in its own right seems not to be responsible for the clinical efficacy of efalizumab and etanercept.