β-Papillomaviruses and psoriasis: an intra-patient comparison of human papillomavirus carriage in skin and hair

Authors

  • J.G. Cronin,

    1. Centre for Cutaneous Research
    2. Centre for Infectious Disease, Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, U.K.
    Search for more papers by this author
  • D. Mesher,

    1. Centre for Epidemiology, Mathematics and Statistics, Barts and the London Queen Mary’s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, U.K.
    Search for more papers by this author
  • K. Purdie,

    1. Centre for Cutaneous Research
    Search for more papers by this author
  • H. Evans,

    1. Centre for Epidemiology, Mathematics and Statistics, Barts and the London Queen Mary’s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, U.K.
    Search for more papers by this author
  • J. Breuer,

    1. Centre for Infectious Disease, Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, U.K.
    Search for more papers by this author
  • C.A. Harwood,

    1. Centre for Cutaneous Research
    2. Centre for Infectious Disease, Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, U.K.
    Search for more papers by this author
  • J.M. McGregor,

    1. Centre for Cutaneous Research
    2. Centre for Infectious Disease, Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, U.K.
    Search for more papers by this author
  • C.M. Proby

    1. Centre for Cutaneous Research
    2. Centre for Infectious Disease, Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, U.K.
    Search for more papers by this author

  • Conflicts of interest
    The authors have no conflicts of interest to declare.

C. Proby.
E-mail: c.proby@dundee.ac.uk

Summary

Background  Human papillomaviruses (HPVs) of the beta genus (β-PV), especially HPV5 and HPV36, are proposed to play a pathogenic role in psoriasis, but many previous studies have failed to control for potential confounders, including treatment.

Objectives  To re-examine the relationship between β-PV and psoriasis addressing limitations present in previous studies and analyse intra-patient concordance for carriage of HPV.

Methods  Plucked eyebrow hairs and forearm skin scrapes were collected from 20 newly diagnosed, previously untreated adult patients with psoriasis and 23 normal controls. A combination of type-specific and degenerate polymerase chain reaction methods was used to achieve comprehensive HPV DNA detection.

Results  The prevalence of HPV in hair and skin from psoriasis patients was higher than in controls (83·3% vs. 46·7%, respectively, < 0·03 corrected for age and clustering). HPV5 or HPV36 were not over-represented. The profile of diverse β-PV types was comparable in the two groups. Intra-patient concordance for HPV DNA at separate sites was high (< 0·00001).

Conclusions  Our data do not support a specific causal role for HPV5 or HPV36 in psoriasis, but suggest that psoriatic skin may be more permissive for viral presence than normal skin. High intra-patient concordance for specific HPV types at separate sites, together with the ubiquity of HPV DNA in normal human skin, suggests that an individual becomes colonized with a particular β-PV profile presumably to the exclusion of other types. To what extent this HPV profile is then causal in the subsequent development of hyperproliferative skin disease is unknown.

Ancillary