Conflicts of interest None declared.
Penile lichen sclerosus after allogeneic stem cell transplantation
Article first published online: 22 MAY 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 159, Issue 2, pages 470–472, August 2008
How to Cite
Au, W.-Y., Yeung, C.-K., Cheung, M.-C. and Trendell-Smith, N.J. (2008), Penile lichen sclerosus after allogeneic stem cell transplantation. British Journal of Dermatology, 159: 470–472. doi: 10.1111/j.1365-2133.2008.08645.x
- Issue published online: 17 JUL 2008
- Article first published online: 22 MAY 2008
- Accepted for publication 29 February 2008
- graft-versus-host disease;
- lichen sclerosus;
Graft-versus-host disease (GVHD) often complicates allogeneic stem cell transplantation (SCT) and affects mainly the gut, liver, lung and skin. The microscopic morphological features of late-phase sclerodermatous chronic GVHD in the skin, namely epidermal atrophy, lymphoplasmacytic infiltration, dense dermal fibrosis and adnexal atrophy, are histologically indistinguishable from those in sporadic systemic sclerosis, morphoea and the related condition of lichen sclerosus. Mucosal orifices including those of the genitourinary system may be severely affected. We present three SCT recipients with chronic GVHD and severe posthitis leading to phimosis requiring surgery. The excised prepuces showed features of lichen sclerosus including epidermal atrophy and a subepidermal zone of eosinophilic, homogeneous and hyalinized collagen above a band-like lymphoplasmacytic infiltrate. These cases add further evidence to support the notion that penile lichen sclerosus should be included within the expanding sclerodermoid spectrum of late-stage cutaneous chronic GVHD.