Conflicts of interest None declared.
Dihydrotestosterone inhibits murine hair growth via the androgen receptor
Article first published online: 28 JUN 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 159, Issue 2, pages 300–305, August 2008
How to Cite
Naito, A., Sato, T., Matsumoto, T., Takeyama, K., Yoshino, T., Kato, S. and Ohdera, M. (2008), Dihydrotestosterone inhibits murine hair growth via the androgen receptor. British Journal of Dermatology, 159: 300–305. doi: 10.1111/j.1365-2133.2008.08671.x
- Issue published online: 17 JUL 2008
- Article first published online: 28 JUN 2008
- Accepted for publication 17 March 2008
- androgenetic alopecia;
- androgen receptor knockout mouse;
- hair cycle
Background Androgens cause regression of human hair follicles in the parietofrontal scalp, but the precise mechanisms by which they do so are unknown. Although many investigators have elucidated the effect of androgens on hair growth by using rodents and other animals, some of the evidence is conflicting.
Objectives To investigate the effect of androgens on mouse hair regrowth and hair cycle by using androgen receptor knockout (ARKO) mice.
Methods We examined the effects of dihydrotestosterone (DHT) on hair regrowth by using ARKO mice and wild-type (WT) littermates, compared the hair cycles in ARKO mice and WT littermates by histology and histomorphometry, and measured hair length and thickness in ARKO mice and WT littermates.
Results DHT inhibited the hair regrowth of WT mice but not that of their ARKO littermates. The anagen phase in the second hair cycle was longer in ARKO mice than in their WT littermates. The hair of ARKO mice was longer and thicker than that of their WT littermates.
Conclusions Androgens inhibit hair growth in mice, and this inhibition might be caused by androgen–androgen receptor signals.