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Genetics of melanoma predisposition

Authors

  • J. Lin,

    1. Department of Dermatology, Harvard Medical School , *Harvard Medical School and †Department of Dermatology , ‡Wellman Center for Photomedicine and §MGH Cancer Center, Massachusetts General Hospital, Boston, MA 02114, U.S.A.
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  • T.L. Hocker,

    1. Department of Dermatology, Harvard Medical School , *Harvard Medical School and †Department of Dermatology , ‡Wellman Center for Photomedicine and §MGH Cancer Center, Massachusetts General Hospital, Boston, MA 02114, U.S.A.
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  • M. Singh,

    1. Department of Dermatology, Harvard Medical School , *Harvard Medical School and †Department of Dermatology , ‡Wellman Center for Photomedicine and §MGH Cancer Center, Massachusetts General Hospital, Boston, MA 02114, U.S.A.
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  • H. Tsao

    1. Department of Dermatology, Harvard Medical School , *Harvard Medical School and †Department of Dermatology , ‡Wellman Center for Photomedicine and §MGH Cancer Center, Massachusetts General Hospital, Boston, MA 02114, U.S.A.
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  • Conflicts of interest
    None declared.

Hensin Tsao.
E-mail: htsao@partners.org

Summary

Over the past 10 years, our understanding of melanoma at the molecular level has blossomed with the advent of genomic technologies. The enormous enthusiasm for the Human Genome Project is slowly being replaced by an even greater excitement for the unravelling of disease genomes, including melanoma. In this review, we will consider some of the clinical implications of these genetic findings for both diagnostics and therapeutics.

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