Conflicts of interest None declared.
Psoriasis and the risk of incident diabetes mellitus: a population-based study
Article first published online: 8 SEP 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 159, Issue 6, pages 1331–1337, December 2008
How to Cite
Brauchli, Y.B., Jick, S.S. and Meier, C.R. (2008), Psoriasis and the risk of incident diabetes mellitus: a population-based study. British Journal of Dermatology, 159: 1331–1337. doi: 10.1111/j.1365-2133.2008.08814.x
- Issue published online: 19 NOV 2008
- Article first published online: 8 SEP 2008
- Accepted for publication 7 June 2008
- body mass index;
- diabetes mellitus;
Background Cross-sectional studies, mostly in hospitalized patients, reported a possible positive association between psoriasis and diabetes mellitus (DM). However, information on the temporal relation is scarce, and incidence rates of new-onset DM in patients with psoriasis are lacking.
Objectives To assess and compare incidence rates of new-onset DM between patients with psoriasis and a comparison group without psoriasis, and to explore the role of psoriasis severity and body mass index (BMI).
Methods We conducted a follow-up study with a nested case–control analysis within the U.K.-based General Practice Research Database. The study population consisted of patients with a first-time diagnosis of psoriasis between 1994 and 2005 and a matched group of psoriasis-free patients. We used psoriasis duration and treatment as proxy for disease severity, and we applied conditional logistic regression to obtain odds ratios (ORs) with 95% confidence intervals (CIs).
Results Within the study population of 65 449 patients we identified 1061 incident cases of DM. Of these, 59% had a history of psoriasis, yielding a crude incidence rate ratio of 1·36 (95% CI 1·20–1·53). The adjusted OR for patients with ≥ 2 years disease duration and > 2 prescriptions per year for oral psoriasis treatment was 2·56 (95% CI 1·11–5·92). In an analysis restricted to patients with normal BMI, the adjusted OR was 2·02 (95% CI 1·31–3·10).
Conclusions In this large observational study the risk of incident DM was increased for patients with psoriasis as compared with a psoriasis-free comparison group. The risk increased with psoriasis duration and severity and was not driven by high BMI alone.