Conflicts of interest None declared.
Sweat antigen induces histamine release from basophils of patients with cholinergic urticaria associated with atopic diathesis
Article first published online: 22 SEP 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 160, Issue 2, pages 426–428, February 2009
How to Cite
Takahagi, S., Tanaka, T., Ishii, K., Suzuki, H., Kameyoshi, Y., Shindo, H. and Hide, M. (2009), Sweat antigen induces histamine release from basophils of patients with cholinergic urticaria associated with atopic diathesis. British Journal of Dermatology, 160: 426–428. doi: 10.1111/j.1365-2133.2008.08862.x
- Issue published online: 16 JAN 2009
- Article first published online: 22 SEP 2008
- Accepted for publication 24 July 2008
- atopic dermatitis;
- atopic diathesis;
- cholinergic urticaria;
- histamine release test;
- sweat antigen
Background We previously demonstrated that the semipurified human sweat antigen causes skin reactions and histamine release from basophils via specific IgE in patients with atopic dermatitis (AD). Patients with cholinergic urticaria (ChU) also develop skin reactions and histamine release of basophils in response to autologous sweat.
Objectives To study whether or not patients with ChU share sensitivity for the sweat antigen with patients with AD and to study the clinical characteristics among patients with ChU and the relationship with histamine-release activity of basophils.
Methods The sweat antigen that induces histamine release from basophils of patients with AD was prepared by Con-A, anion-exchange and reverse-phase chromatography. Relationships between histamine-release activity against the sweat antigen and clinical features of patients with ChU were analysed.
Results Twenty-three of 35 patients with ChU showed > 5% net histamine release in response to the semipurified sweat antigen, whereas none of healthy controls did so. In patients with ChU, histamine release in response to semipurified sweat antigen significantly correlated with the level of serum IgE and eosinophil numbers in peripheral blood. Incidence of each atopic disease in patients with ChU tended to be higher than in the general Japanese population. When the patients were categorized according to their responses in the histamine release test, the positive group tended to show a higher incidence of AD and bronchial asthma compared with the negative group.
Conclusions ChU and AD may share hypersensitivity to common antigens in sweat. The sweat allergy and atopic diathesis are associated with each other.