Conflicts of interest None declared.
Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model
Article first published online: 20 OCT 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 160, Issue 2, pages 284–296, February 2009
How to Cite
Stenderup, K., Rosada, C., Worsaae, A., Dagnaes-Hansen, F., Steiniche, T., Hasselager, E., Iversen, L.F., Zahn, S., Wöldike, H., Lindgreen Holmberg, H., Rømer, J., Kragballe, K., Clausen, J.T. and Dam, T.N. (2009), Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model. British Journal of Dermatology, 160: 284–296. doi: 10.1111/j.1365-2133.2008.08890.x
- Issue published online: 16 JAN 2009
- Article first published online: 20 OCT 2008
- Accepted for publication 19 July 2008
- SCID mice
Background Interleukin (IL)-20 is a recently discovered cytokine displaying increased levels in psoriatic lesions. Interestingly, IL-20 levels decrease with antipsoriatic treatment, correlating with clinical improvement. However, the role of IL-20 in the aetiology of psoriasis is unknown.
Objectives In this study, we investigate the effects both of blocking IL-20 signalling in psoriatic plaques and of adding IL-20 to nonlesional psoriasis skin.
Methods We employed the human skin xenograft transplantation model in which psoriatic plaques and nonlesional keratome skin biopsies obtained from donors with moderate to severe plaque psoriasis were transplanted on to immuno-deficient mice. The transplanted mice were treated with anti-IL-20 antibodies or recombinant human IL-20.
Results We demonstrate that blocking IL-20 signalling with anti-IL-20 antibodies induces psoriasis resolution and inhibits psoriasis induction. We also demonstrate that continuous IL-20 infusion, together with injection of additional nonactivated leucocytes, promotes induction of psoriasis in nonlesional skin from patients with psoriasis.
Conclusions The results suggest that IL-20 plays a critical role in the induction and maintenance of psoriasis, and IL-20 is suggested as a new possible specific target in psoriasis treatment.