Conflicts of interest None declared.
Biomarkers of Th2 polarity are predictive of staphylococcal colonization in subjects with atopic dermatitis
Article first published online: 28 OCT 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 160, Issue 1, pages 183–185, January 2009
How to Cite
Warner, J.A., McGirt, L.Y. and Beck, L.A. (2009), Biomarkers of Th2 polarity are predictive of staphylococcal colonization in subjects with atopic dermatitis. British Journal of Dermatology, 160: 183–185. doi: 10.1111/j.1365-2133.2008.08905.x
- Issue published online: 15 DEC 2008
- Article first published online: 28 OCT 2008
- Accepted for publication 19 August 2008
- atopic dermatitis;
- Staphylococcus aureus
Background Staphylococcal colonization of the skin is commonly observed in subjects with atopic dermatitis (AD) and correlates with disease severity. Little is known about whether the degree of T-helper 2 (Th2) polarity in these subjects can also affect the frequency of bacterial colonization in this disease.
Objectives To determine if there is a correlation between markers of Th2 polarity [serum total IgE, eosinophilia and presence of another atopic disease (allergic rhinitis)] and skin colonization with Staphylococcus aureus in subjects with AD.
Methods A retrospective chart review was performed of an academic dermatology clinic focused on the treatment of AD with a single provider.
Results Staphylococcus aureus colonization was more commonly observed in subjects with AD who had peripheral eosinophilia, elevated serum IgE levels, and/or a history of or active allergic rhinitis.
Conclusions Results suggest that Th2 polarity may enhance subjects’ risk for bacterial colonization.