Biomarkers of Th2 polarity are predictive of staphylococcal colonization in subjects with atopic dermatitis

Authors


  • Conflicts of interest
    None declared.

Lisa A. Beck.
E-mail: Lisa_Beck@URMC.Rochester.edu

Summary

Background  Staphylococcal colonization of the skin is commonly observed in subjects with atopic dermatitis (AD) and correlates with disease severity. Little is known about whether the degree of T-helper 2 (Th2) polarity in these subjects can also affect the frequency of bacterial colonization in this disease.

Objectives  To determine if there is a correlation between markers of Th2 polarity [serum total IgE, eosinophilia and presence of another atopic disease (allergic rhinitis)] and skin colonization with Staphylococcus aureus in subjects with AD.

Methods  A retrospective chart review was performed of an academic dermatology clinic focused on the treatment of AD with a single provider.

Results Staphylococcus aureus colonization was more commonly observed in subjects with AD who had peripheral eosinophilia, elevated serum IgE levels, and/or a history of or active allergic rhinitis.

Conclusions  Results suggest that Th2 polarity may enhance subjects’ risk for bacterial colonization.

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