Conflicts of interest None declared.
Patch test dose–response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals
Article first published online: 11 NOV 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 160, Issue 1, pages 103–106, January 2009
How to Cite
Carlsen, B.C., Fischer, L.A., Sosted, H., Vølund, A., Menné, T. and Johansen, J.D. (2009), Patch test dose–response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals. British Journal of Dermatology, 160: 103–106. doi: 10.1111/j.1365-2133.2008.08921.x
- Issue published online: 15 DEC 2008
- Article first published online: 11 NOV 2008
- Accepted for publication28 August 2008
- elicitation dose–response relationship;
- methyldibromo glutaronitrile;
- nickel sulphate;
Summary Background It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group.
Objectives To examine and compare elicitation dose–response curves and elicitation thresholds in a polysensitized vs. a single/double-sensitized group for allergens to which the test subjects were already sensitized.
Patients/methods Fifty-one patients (13 polysensitized and 38 single/double-sensitized) were patch tested with nickel sulphate, methyldibromo glutaronitrile (MDBGN) and p-phenylenediamine (PPD) in dilution series. The ratio between the doses eliciting a response in 50% of patients in the two groups was used as the measure for relative sensitivity.
Results The dose–response curves of the polysensitized group for MDBGN and PPD were shifted to the right, and for nickel sulphate shifted to the left, compared with the single/double-sensitized group. The relative sensitivity for each of the three allergens and a combined relative sensitivity for all three allergens were not significantly different when comparing the polysensitized and single/double-sensitized groups.
Conclusion No increased sensitivity, in the form of distinct elicitation thresholds, could be demonstrated in polysensitized individuals compared with individuals with one or two contact allergies.