Conflicts of interest None declared.
Pulsed dye laser vs. intense pulsed light for port-wine stains: a randomized side-by-side trial with blinded response evaluation
Article first published online: 16 DEC 2008
© 2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists
British Journal of Dermatology
Volume 160, Issue 2, pages 359–364, February 2009
How to Cite
Faurschou, A., Togsverd-Bo, K., Zachariae, C. and Hædersdal, M. (2009), Pulsed dye laser vs. intense pulsed light for port-wine stains: a randomized side-by-side trial with blinded response evaluation. British Journal of Dermatology, 160: 359–364. doi: 10.1111/j.1365-2133.2008.08993.x
- Issue published online: 16 JAN 2009
- Article first published online: 16 DEC 2008
- Accepted for publication 14 October 2008
- intense pulsed light;
- port-wine stains;
- pulsed dye laser;
- randomized clinical trial
Background Pulsed dye lasers (PDLs) are considered the treatment of choice for port-wine stains (PWS). Studies have suggested broadband intense pulsed light (IPL) to be efficient as well. So far, no studies have directly compared the PDL with IPL in a randomized clinical trial.
Objectives To compare efficacy and adverse events of PDL and IPL in an intraindividual randomized clinical trial.
Methods Twenty patients with PWS (face, trunk, extremities; pink, red and purple colours; skin types I–III) received one side-by-side treatment with PDL (V-beam Perfecta, 595 nm, 0·45–1·5 ms; Candela Laser Corporation, Wayland, MA, U.S.A.) and IPL (StarLux, Lux G prototype handpiece, 500–670 and 870–1400 nm, 5–10 ms; Palomar Medical Technologies, Burlington, MA, U.S.A.). Settings depended on the preoperative lesional colour. Treatment outcome was evaluated by blinded, clinical evaluations and by skin reflectance measurements.
Results Both PDL and IPL lightened PWS. Median clinical improvements were significantly better for PDL (65%) than IPL (30%) (P = 0·0004). A higher proportion of patients obtained good or excellent clearance rates with the PDL (75%) compared with IPL (30%) (P = 0·0104). Skin reflectance also documented better results after PDL (33% lightening) than IPL (12% lightening) (P = 0·002). Eighteen of 20 patients preferred to receive continued treatments with PDL (P = 0·0004). No adverse events were observed with PDL or IPL.
Conclusions Both the specific PDL and IPL types of equipment used in this study lightened PWS and both were safe with no adverse events. However, the PDL conveyed the advantages of better efficacy and higher patient preference.