Conflicts of interest None declared.
Depressive symptoms predict the future risk of severe pruritus in haemodialysis patients: Japan Dialysis Outcomes and Practice Patterns Study
Version of Record online: 9 MAR 2009
© 2009 The Authors. Journal Compilation © 2009 British Association of Dermatologists
British Journal of Dermatology
Volume 161, Issue 2, pages 384–389, August 2009
How to Cite
Yamamoto, Y., Hayashino, Y., Yamazaki, S., Akiba, T., Akizawa, T., Asano, Y., Saito, A., Kurokawa, K., Miyachi, Y. and Fukuhara, S. (2009), Depressive symptoms predict the future risk of severe pruritus in haemodialysis patients: Japan Dialysis Outcomes and Practice Patterns Study. British Journal of Dermatology, 161: 384–389. doi: 10.1111/j.1365-2133.2009.09088.x
- Issue online: 21 JUL 2009
- Version of Record online: 9 MAR 2009
- Accepted for publication 9 December 2008
- longitudinal studies;
- renal dialysis
Background Recent reports suggest a cross-sectional association between psychiatric distress and pruritus in patients on haemodialysis (HD). However, no study has examined the likelihood of developing severe pruritus in patients on HD with depressive symptoms.
Objectives To evaluate the relationship between baseline depressive symptoms and subsequent risk of developing severe pruritus.
Methods A longitudinal study with a 0·5–2·5-year follow-up period was performed using 1799 patients on HD who had no/mild pruritus at baseline, based on the Japan Dialysis Outcomes and Practice Patterns Study (1996–2004), a cohort study composed of a representative sample of patients on HD. We assessed pruritus after the follow-up period using a self-reported questionnaire and depressive symptoms using scores from the five-item version of the Mental Health Inventory (MHI-5).
Results The 1799 patients had a mean age of 56·9 years, 59·5% were men, and 23·6% presented depressive symptoms. Multivariable analysis revealed that patients with depressive symptoms had significantly higher odds of developing severe pruritus during the 0·5–2·5-year follow-up period [adjusted odds ratio (AOR) 1·57, 95% confidence interval 1·22–2·01, P < 0·001]. In addition, a significant linear trend was observed between baseline MHI-5 scores and risk of developing severe pruritus, with AORs for third, second and first MHI-5 score quartiles of 1·08, 1·51 and 1·95, respectively (P for trend < 0·0001).
Conclusions Our results suggest that depressive symptoms measured by MHI-5 may predict the future risk of developing severe pruritus in patients on HD.