Conflicts of interest None declared.
Epidermal stem cells: practical perspectives and potential uses
Article first published online: 22 APR 2009
© 2009 The Authors. Journal Compilation © 2009 British Association of Dermatologists
British Journal of Dermatology
Volume 161, Issue 2, pages 228–236, August 2009
How to Cite
Abbas, O. and Mahalingam, M. (2009), Epidermal stem cells: practical perspectives and potential uses. British Journal of Dermatology, 161: 228–236. doi: 10.1111/j.1365-2133.2009.09250.x
- Issue published online: 21 JUL 2009
- Article first published online: 22 APR 2009
- Accepted for publication 7 April 2009
- stem cells
Throughout adult life, the epidermis and the hair follicle undergo a perpetual cycle of growth, regression and rest. Stem cells in the epidermis not only ensure the maintenance of epidermal homeostasis and hair regeneration, but also contribute to repair of the epidermis after injury. These stem cells lie within specific niches in the hair follicle and the epidermis. The availability of monoclonal antibodies that can be used on formalin-fixed paraffin-embedded tissue has greatly facilitated the use of this methodology as an adjunct to uncovering stem cell niches. In this review, we attempt to provide an overview of the potential markers available to identify and study stem cells in an effort to providing a better understanding of the pathogenesis of skin diseases including disorders of hair loss and malignancies. The potential uses of these markers in prognosis and in expanding the therapeutic options in several disorders will also be addressed.