Conflicts of interest R.D.R.C. has recently received an honorarium for consulting from Actimis Pharmaceuticals and holds shares in this company. A.B.A. has received an educational grant from Merck Serono.
More than skin deep: atherosclerosis as a systemic manifestation of psoriasis
Version of Record online: 4 JUN 2009
© 2009 The Authors. Journal Compilation © 2009 British Association of Dermatologists
British Journal of Dermatology
Volume 161, Issue 1, pages 1–7, July 2009
How to Cite
Alexandroff, A.B., Pauriah, M., Camp, R.D.R., Lang, C.C., Struthers, A.D. and Armstrong, D.J. (2009), More than skin deep: atherosclerosis as a systemic manifestation of psoriasis. British Journal of Dermatology, 161: 1–7. doi: 10.1111/j.1365-2133.2009.09281.x
- Issue online: 22 JUN 2009
- Version of Record online: 4 JUN 2009
- Accepted for publication 13 March 2009
- cardiovascular disease;
- metabolic syndrome;
- tumour necrosis factor-α
There is now growing evidence that psoriasis, like other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus, is a systemic disorder that is associated with enhanced atherosclerosis and risk of coronary artery disease. Here we summarize the available epidemiological evidence for this association and analyse pathogenic features that are common to psoriasis and atherosclerosis. Further prospective studies are urgently needed to extend knowledge of the risk of cardiovascular morbidity and mortality in patients with psoriasis and to confirm the degree to which treatment of psoriasis reduces this risk. Nevertheless, existing data are sufficient to indicate that severe psoriasis should be more widely recognized as a potential risk factor for cardiovascular disease and should be considered with the established factors when formulating strategies for the management of cardiovascular risk.