Conflicts of interest None declared.
Diversity of human papillomavirus types in periungual squamous cell carcinoma
Article first published online: 11 JUN 2009
© 2009 The Authors. Journal Compilation © 2009 British Association of Dermatologists
British Journal of Dermatology
Volume 161, Issue 6, pages 1262–1269, December 2009
How to Cite
Kreuter, A., Gambichler, T., Pfister, H. and Wieland, U. (2009), Diversity of human papillomavirus types in periungual squamous cell carcinoma. British Journal of Dermatology, 161: 1262–1269. doi: 10.1111/j.1365-2133.2009.09343.x
- Issue published online: 17 NOV 2009
- Article first published online: 11 JUN 2009
- Accepted for publication 27 May 2009
- human α and β papillomavirus;
- periungual squamous cell carcinoma
Background There is accumulating evidence that infections with certain high-risk α-human papillomaviruses (HPVs) are involved in the pathogenesis of digital squamous cell carcinomas (SCCs) and their precursor lesions (SCCs in situ).
Objectives This study was initiated to search for α- and β-HPV infections in a collective of SCC and SCC in situ located on the hands.
Methods HPV typing for 36 high-risk and low-risk α-HPV types and 25 β-HPV types was performed in SCCs located at different sites of the hands. Additionally, immunohistochemical staining for p16INK4a and Ki67 was performed in 15 samples.
Results In total, 25 SCCs/SCCs in situ (six periungual lesions, eight lesions from the proximal or lateral part of the finger, and 11 lesions from the dorsal part of the hand) were analysed for the presence of α- and β-HPV types. Only one lesion (an SCC in situ positive for HPV11 and HPV31) of the dorsal hand and none of the proximal or lateral part finger lesions were α-HPV positive. In contrast, all six periungual lesions were α-HPV positive, and the majority (83%) of them carried HPV types other than HPV16 (HPV26, HPV33, HPV51, HPV56 and HPV73). β-HPV types were found in only two biopsies. p16INK4a and Ki67 expression was significantly higher in HPV-positive lesions as compared with HPV-negative tumours, and both markers significantly correlated with each other.
Conclusions In contrast to other locations of the hands, periungual SCCs are frequently associated with α-HPV infections. Several high-risk HPV types other than HPV16 can induce periungual SCCs. Given the high recurrence rate and high proliferative activity of HPV-associated periungual SCCs, aggressive treatment and close follow-up of these tumours is mandatory.